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Goblet cell hyperplasia leads to hypersecretion of mucus by goblet cell, and less mucus clearance leads to airway inflammation, structural changes, and obstruction in airways mainly luminal obstruction of small airways, epithelial remodeling, accelerated lung function decline, and alteration of airway surface tension predisposing to collapse of patients with chronic bronchitis

Many commercial preparations combine glucosamine with other ingredients, including chondroitin, methylsulfonylmethane (MSM), or various additives and fillers

The risk of weight gain and hypoglycemia can also be reduced with this combination therapy