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involving over 18,000 patients found that while general complications were rare and comparable between patients undergoing surgery for autoimmune thyroid disease and those with multinodular goitre, the risk of transient (15.3%) and permanent (1.1%) hypoparathyroidism was significantly higher in HT patients than in those undergoing surgery for multinodular goitre (12.9% and 0.9%, respectively) (57)

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The glucagon receptor component does not appear to cause significant glucose-raising effects in the context of GLP-1 co-activation, suggesting that the three receptor pathways balance each other in important ways