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Glutamate-cysteine ligase catalytic and modulator subunits as well as GSH synthetase are the three NRF2 targets involved in the GSH synthesis (242)
Integration with cellular copper homeostasis GSH functions within a broader copper homeostasis network that includes metallothioneins (MTs), a family of small, cysteine-rich proteins essential for metal detoxification and redox buffering 171,172
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