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These agents mimic the action of glucagon-like peptide-1, stimulating insulin secretion, slowing gastric emptying, and promoting satiety

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Neuronal effects of GLP-1MK-801 To understand the biological underpinnings of the metabolic benefits of GLP-1MK-801, we performed RNA sequencing (RNA-seq) and MS-based proteomics analyses on hypothalami from DIO mice treated with vehicle, GLP-1, MK-801 or the GLP-1MK-801 conjugate for 5 days (Fig

JAMA Netw Open 2022;5:E221169