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This gives Lantus a relatively flat profile with no strong peak, which helps: Keep fasting and between-meal glucose levels more stable Reduce the risk of overnight lows compared with older intermediate insulins Provide a predictable background on which to build your overall treatment plan In people with type 1 diabetes, Lantus replaces the background insulin that the pancreas can no longer produce

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These effects can lead to oxidative stress, DNA injury, and apoptosis [79]