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It appeared to lower the intensity of H2AX signals a marker of DNA damage and seemed to decrease apoptosis rates, as indicated by reduced Annexin-V staining

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Axitinib decreases the disruption of tight junction proteins and reduces permeability of the BBB in AD disease mice while also increasing spatial awareness, exploration, associative memory, working memory and lowered amyloid-beta, indicating the potential for this drug to slow disease pathology [136]

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