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16 Figure 3: Risk of OACs in patients on GLP-1s versus patients on insulin Conclusion GLP-1s, initially developed to help manage and treat diabetes and later used to treat obesity, are now showing significant potential to help prevent and treat CVD, mental health disorders, liver and kidney disorders, neurodegenerative disorders, addiction disorders, and cancer

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and (iii) mitochondrial pyruvate carrier suppression, limiting pyruvate entry into mitochondria to attenuate oxidative respiration (2729)