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Together, findings from these two studies [25, 28] may suggest that antidepressants should generally not be used in two-thirds of patients with bipolar depression who present with subtly increased psychomotor tempo, pressured speech and racing thoughts

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Substrate receptor proteins, such as von Hippel-Lindau tumor suppressor (VHL), suppressor of cytokine signaling (SOCS) (24), the ASB-box protein family (25), iral proteins (e.g., Vif, viral infectivity factor) (26, 27), F-box (28), and Bric-a-brac/Tramtrack/Broad-complex (BTB) domains (29), are responsible for directly recognizing substrates and determining enzymatic specificity (20, 30)