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Lipid peroxidation of unsaturated fatty acids produces lipid peroxyl radicals (ROO), which diffuse easily in biological systems

Ecklu-MensahGChoo-KangCMasengMGDonatoSBovetPViswanathanBet al

Pharmacological inhibition of the MVA pathway impairs Sec-tRNA biogenesis, leading to GPX4 inactivation, diminished cellular antioxidant defenses, lipid peroxide accumulation, and ultimately ferroptosis induction ( Recent studies demonstrate that the bisphosphonate alendronate synergistically enhances paclitaxel efficacy, suppresses tumor metastasis, and modifies cytotoxic mechanisms in cancer therapy

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