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Prednisone, like other corticosteroids should not be administered concomitantly with: - Barbiturates, carbamazepine, phenytoin, rifampin or ephedrine: these drugs enhance the metabolism of corticosteroids reducing their therapeutic action

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The injection site When people complain about arm or leg pain after B12 injections, its often because of intramuscular delivery

If you don't treat your B12 deficiency, it can lead to more severe neurological problems, including: Problems walking or speaking Vision loss Numbness or tingling Muscle weakness Difficulty remembering things Depression or mood swings Treating vitamin B12 deficiency Treatment depends on the reason for your low levels of B12