People with active peptic ulcers should use NAC cautiously due to its potential to irritate the gastrointestinal tract
1 The 2023 International Evidence-Based Guideline for the Assessment and Management of PCOS, developed by Monash University in partnership with ESHRE, ASRM, the Endocrine Society, and the European Society of Endocrinology, 11 made several practice-defining points
The functional assays of CYP3A4 further validate this claim: iHLOs exhibited a concentration-dependent inhibition profile following ketoconazole treatment (IC 50 : 0.83 M), comparable to HepaRG cells but distinct from PHHs
Based on the data available in 2015, EFSA did not identify any known health risks associated with the use of dietary supplements, so no maximum dose or maximum daily intake, also known as a tolerable upper intake, was set (EFSA, 2015)