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In adults, alpha-cell progression to maturity was hindered, the mRNA levels of several beta-cell genes (GLUT2, pancreatic duodenal homeobox-1 (PDX-1), and Maf-A) involved in insulin production and secretion were decreased, and there was an increase in the number and rate of proliferation of islet alpha-, beta- and delta-cells

Latest study showing efficacy of nonpeptide oral GLP-1R agonists currently under development

121,134 GIP, another insulin secretion agonist, helps release insulin, particularly after eating, enhancing the effects of GLP-1 and thereby improving the overall therapeutic efficacy of the drug

Coskun, T., Urva, S., Loh, M