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Both in vitro and in vivo studies have provided evidence that Ex-4 can significantly inhibit breast cancer cell proliferation by suppressing NF-B signaling activation and the expression of its downstream target genes, vascular endothelial growth factor (VEGF) and interleukin-8(IL-8) [55]

CJC-1295 shows similar characteristics, though the DAC (Drug Affinity Complex) modified version may exhibit slightly different degradation kinetics