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Besides their role in inflammation, these cytokines are detrimental to the processes of fertilization and embryo development: TNF- increases the free implants adhesions and their invasiveness through its effect on matrix metallo-proteinases (157) while TGF- hinders the local immune activity by inhibiting the natural killer cells which in turn impede the development of embryos (158)

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Manufacturers can choose to collaborate with strong and reputable distributors to jointly develop sales strategies and marketing plans