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In vitro , butyrate increased the expression of mitogen-activated protein kinase phosphatase-1 (MKP-1), which dephosphorylates activated c-Jun N-terminal kinase (JNK), ERK1/2, and p38 Mitogen-activated protein kinase (MAPK) to counteract excessive inflammation in RAW264.7 macrophages (214)

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The compound has attracted significant interest in preclinical research for its effects on adipocyte metabolism, body composition, and muscle function in animal models