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To increase the chance of spotting melanoma early, recommend: A self-skin examination monthly A patient noticing a significant change in a mole or a new lesion should show this to their doctor or dermatologist Regular skin examinations in patients with many naevi, atypical naevi, or who have had a previous skin cancer Total body photography and digital dermatoscopic imaging (mole mapping) for patients at high risk of melanoma, especially if they have many melanocytic naevi

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Additionally, if gut permeability is indeed increased in ME/CFS patients, microbes and antigens may be able to cross the epithelial barrier into surrounding tissue and blood, potentially crossing the BBB and altering the HPA axis (443)

You said no, of course we know why it works