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[12] Individuals with the MTHFR gene variation may also have a difficult time processing folic acid (a manufactured version of folate that is present in low-quality multivitamins and added to processed foods)

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Gastrointestinal side effects (diarrhoea, nausea, abdominal discomfort) are relatively common with both supplements, particularly when starting treatment

Vitamins from the B group are recommended during pregnancy