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These include hydroxyl, superoxide and nitric oxide radicals, hydrogen peroxide, singlet oxygen, hypochlorous acid (HOCl), and peroxynitrite (Figure 1)

Clinically, LOAD begins with episodic memory decline and gradually advances to involve executive dysfunction (Kelly et al., 2020) language disturbances (Paolini Paoletti et al., 2021) and impaired daily living (Guo et al., 2022)

Yang Z, Li T, Li S, Wei M, Qi H, Shen B, Chang RC, Le W, Piao F (2019a) Altered Expression Levels of MicroRNA-132 and Nurr1 in Peripheral Blood of Parkinsons Disease: Potential Disease Biomarkers

Source: PubMed 9920688