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Oxidative stress affects antioxidant enzymes and other molecules, reduces GSH, and increases cisplatin toxicity ( Figure 1 2 Research progress on the premature ovarian failure induced by cisplatin chemotherapy 2.1 Factors influencing premature ovarian failure The average age of menopause for women is between 50 and 52 years, at which point the ovarian function declines

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The excited oxygen molecule decomposes into reactive oxygen species (ROS): excited state of bimolecular oxygen and superoxide anion radical