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Beyond vesicular signaling, specific stromal subpopulations such as THBS2 CAFs promote resistance through the paracrine secretion of factors like COL8A1, which can induce epithelial-mesenchymal transition (EMT) and activate the PI3K/AKT axis in tumor cells, thereby blocking the cytotoxicity of agents such as oxaliplatin [104]

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Metabolic health improved significantly over 12 weeks: she experienced a 9.4% loss of body weight (21.5 lbs/9.8 kg) and 3.2% decrease in body fat percentage (45.3 to 42.1%)