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GLP-1 levels can predict CAS in patients with newly diagnosed T2DM to some extent, and the optimal GLP-1 level of it is 6.59 pmol/L

4.1 Exendin 4-based agents Exendin-4, a 39-amino acid peptide with 53% sequence homology to human GLP-1 [ Figure 2 ], was originally isolated from Heloderma suspectum lizard venom by using an amino acid sequencing assay targeting peptides with an amino-terminal histidine residue (His 1 ) (83)

This timely adjustment reduces dropout rates and minimizes the emotional fatigue associated with repeated treatment disappointment, supporting better continuity and overall success

Exendin-4 was ultimately synthesized to Exenatide, a GLP-1RA with a half-life sufficient to permit clinical use in treating type 2 diabetes, the first in a new generation of drugs that followed