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These data uncover essential pathways for prediabetes remission without weight loss and emphasize the need to include glycemic targets in current clinical practice guidelines to improve T2D prevention

Lipopolysaccharide (LPS) treatment The experimental administration of LPSs, molecules from the outer membrane of Gram-negative bacteria, to induce an inflammatory response in the lungs, simulating conditions such as acute respiratory distress syndrome for research purposes

This color shift indicates oxidation products forming in the solution

Dose-response studies show therapeutic effects from 10 g/kg to 10 mg/kg in rats with no reported adverse events, suggesting a broad therapeutic window that would extrapolate to 50250 mg in humans