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Of interest is the existence of two interfacial hydrogen bonds (Table 5) between the side chains of Arg123 and Arg127, which constitute an additional set of attractive forces for the structural stability of the cluster of three charged residues (Figures 3 and 4) consisting of Arg123, Arg127 and Glu40

doi: 10.3389/fendo.2025.1562653 Received 17 January 2025 Accepted 31 March 2025 Published 17 April 2025 Volume 16 - 2025 Edited by Prem Prakash Kushwaha, Case Western Reserve University, United States Reviewed by Ankit Kushwaha, Stanford University, United States Saurabh Mishra, Cleveland Clinic, United States Updates Copyright 2025 Zong, Wang, Chen, Fang and Zhang

It is important to note that candidates must be prepared to make healthy lifestyle changes, as the medication is most effective when patients follow a healthy diet and exercise routine