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By targeting NNMT an enzyme elevated in adipose tissue it alters downstream metabolic signaling independent of hormonal pathways

Nature 477 , 9094 (2011)

doi:10.1016/j.redox.2013.08.006 Lin SX, Lisi L, Russo CD, Polak PE, Sharp A, Weinberg G, Kalinin S, Feinstein DL (2011) The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1

Valproate-phenobarbital interaction: [1] Valproate may reduce phenobarbital metabolism