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Improvements were even more pronounced at last follow-up, with 62% achieving 1-point HS-PGA reduction and 32% achieving 2 points

In addition, using lysophosphatidylcholine-induced demyelination in the optic chiasm revealed that metformin treatment attenuates lysophosphatidylcholine-induced demyelination and protects functional conductivity of the optic tract (Esmaeilnejad et al., 2021)