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In the lead-up to the migraine, alterations in the connectivity between the hypothalamus, brainstem, spinal trigeminal nuclei, and the dorsal rostral pons in the hindbrain have been noted as early as 48 h before the pain onset

The implication of this self-perpetuating cycle is that oxidative stress is not merely a bystander but an active driver of OA progression, creating a feed-forward loop where inflammation begets more oxidative stress, and vice versa

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