Although your body makes it on its own, stress, poor diet, toxins, and aging can lower its levels
Pre-Existing Nutritional Deficiencies If you start GLP-1 therapy already low in iron (ferritin), vitamin D, B12, zinc, biotin, or folate, youre at elevated risk
The CDX2 gene plays an important role in this transformation process
Additionally, hypertrophic adipocytes release TNF-, IL-6, and MCP-1, reinforcing the inflammatory state and perpetuating insulin resistance Figure 3 ( Figure 3 Recent single-cell transcriptomic studies have identified distinct macrophage populations such CD9 + macrophages in obese adipose tissue that display both inflammatory and pro-fibrotic phenotypes (36, 37)