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109 These controversial findings may be attributed to issues of dosing strategy, statistical bias, 110 and the clinical stage of MASLD

Morgan James from the University of Sydney (Horizon Fellowship), the National Institute on Drug Abuse (R00 DA04765 and R37 DA061303), the National Heart, Lung, and Blood Institute (U01HL150852), Rutgers Optimizes Innovation, the New Jersey Health Foundation (PC144-23 and PC98-22), and an International Collaborative Research Grant from Rutgers Global

In the semaglutide group, DEGs were primarily involved in lipid metabolism, fatty acid oxidation, ATP biosynthesis, and oxidoreductase activity

The doses of these drugs used with cells were based on previous data [34,35,36]