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These pathological pathways are probably mediated, at least in part, through NLRP3 inflammasome stimulation and mitochondrial disruption

Results A total of 267 dysregulated metabolites were identified in patients with MMA, including 185 upregulated and 82 downregulated metabolites

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The direct management of hypertension using antihypertensive agents (e.g., angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers) in midlife and later has been extensively explored as a strategy for the prevention of dementia, and many observational studies have suggested that the use of antihypertensive agents has a beneficial effect on the prevention of dementia (Olmastroni et al., 2022