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7.2.3 Studies of underlying mechanisms Elucidating the molecular interactions among agents used in combination therapy is essential for optimizing dose selection, minimizing adverse effects, and avoiding mechanistic redundancy

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Beran M, Kantarjian H, O'Brien S, Koller C, al-Bitar M, Arbuck S, Pierce S, Moore M, Abbruzzese JL, Andreeff M , Keating M, Estey E

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