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Dormancy is further stabilized by intrinsic regulators such as lncRNA NR2F1-AS1, which regulates stemness to prevent metastatic activation, and laminin-211 from the astrocytes in the brain, which maintains quiescence through dystroglycan signaling (163)

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The abundance of histamine means the ALDH enzyme system capacity is being used up getting rid of histamine, so theres not enough capacity to deal with the excess histamine or to deal with aldehydes when exposures occur