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Nausea, vomiting, diarrhoea, decreased appetite, constipation, and abdominal discomfort are most common, usually during the dose-escalation period, and typically improve with time

Stopping the medication may lead to a return of appetite and potential weight regain

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According to the report, Harlan Krumholz, a professor of medicine at Yale University who edits the Journal of the American College of Cardiology where the studies were published, said that the drug was "somehow quieting inflammation," adding that the benefit was "broad there's not a group that doesn't seem to be benefiting." "Is it a fountain of youth I would say if you're improving someone's cardiometabolic health substantially, then you are putting them in a position to live longer and better," he continued