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The adhesion molecule P-selectin and cardiovascular disease

The problem is that the digestive process, particularly stomach acid and the enzyme gamma-glutamyltransferase present in the gut lumen, can cleave glutathione into its constituent amino acids (glutamate, cysteine, glycine) before it is absorbed intact

However, adverse effects may limit the treatment potential, e.g., glitazones are associated with phenotypical weight gain [136] and obeticholic acid induced pruritus and elevated LDL-C [137], the latter a potential concern in patients already at risk for cardiovascular disease

Bradley, R., Fitzpatrick, A.L., Jenny, N.S., Lee, D.-H