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In the treatment with three active ingredients the subjects were administered for 16 weeks daily dosing of 5 grams of hydrolyzed collagen (HC) with 80 mg of vitamin C and 30 mg of hyaluronic acid (triple treatment n = 28)

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It usually increases rapidly in size to several centimetres and is characterised by acanthosis and spongiosis of the affected epithelium with dendritic melanocytes dispersed throughout the thickness of the epithelium, with a mild inflammatory cell infiltrate in the superficial lamina propria [11, 13, 34]

Collagen supports structure