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However, a PTHrP 134 maintains a less pronounced anabolic effect to the bone and osteoblasts possibly due its higher clearance rate [52, 53]

However, phlebotomy cannot be used in patients with significant anemia, malignancy, or hemodynamic instability, and chelation therapy has an inherent risk of toxicity (4, 40, 41)

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SAM-e plays a central role in cellular biochemistry, acting as a donor of methyl groups in numerous methylation reactions as well as being a precursor molecule to both the aminopropylation and transulfuration pathways