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The early appearance of perfusion abnormalities emphasizes their potential role as prodromal indicators, accentuating the importance of proactive vascular surveillance in individuals at risk for neurodegenerative diseases

Although the described findings predominantly originate from in cell line studies and animal experiments, a recent clinical study involving around 80 patients with mild cognitive impairment suggests that melatonin supplementation may also exhibit anti-tauogenic potential in humans

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No pode ser administrado a humanos ou animais fora de ensaios clnicos aprovados