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However, the PRMR Hospital Recommendation Group members expressed concerns about lack of testing in the ASC setting given differences between HOPDs as a hospital setting (where testing of the Information Transfer PRO-PM was conducted) and ASCs

While theoretically closer to the injury, it doesnt offer the same direct concentration as a true local injection and lacks the simplicity of a standard abdominal subcutaneous injection

These findings consistently emphasize the importance of changes in the concentrations of various ions in the extracellular environment of neurons, and it is possible that targeting the concentrations of ions in the environment to permanently regulate the splicing of neurexins and thereby interfere with synaptic plasticity could be one of the mechanisms of sustained antidepressant effect

J Pharmacol Exp Ther 2014;351:390-402