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Stress-mediated signaling in PC12 cells - the role of the small heat shock protein, Hsp27, and Akt in protecting cells from heat stress and nerve growth factor withdrawal

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Summary The prevailing view on the role of glutathione in protein disulphide-bond formation is that this tripeptide acts as a net reductant in the ER, either by maintaining ER oxidoreductases in a reduced state or by directly reducing non-native disulphide bonds in substrate folding proteins

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