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Nonetheless, this link further confirms the interaction between the liver and brain in AD

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Yet, overproduction of reactive oxygen species (ROS), induced by environmental toxins, inflammation, or mitochondrial dysfunction, overwhelms the cellular antioxidant defense system, resulting in oxidative stress [27]

5,6 DNA damage is also linked to neurodegenerative disorders, with the accumulation of DNA lesions in neurons being associated with Alzheimers, Huntingtons and Parkinsons diseases