MD analysis The mean binding free energies from all MD simulations are 30.2195 1.6479 kcal/mol for Arbutin_a, 12.4682 1.8569 kcal/mol for Arbutin_b, 30.8403 1.4281 kcal/mol for Arbutin_c, and 28.0049 0.8462 kcal/mol for Arbutin_d

Call 911 or seek emergency medical attention immediately if you experience: Severe or persistent dizziness that prevents normal activities Lightheadedness accompanied by chest pain, shortness of breath, or irregular heartbeat Fainting or loss of consciousness Dizziness with severe headache, vision changes, or difficulty speaking Signs of severe dehydration (dark urine, extreme thirst, confusion, minimal urination) Severe abdominal pain, especially if radiating to the back (possible pancreatitis) Severe pain in the upper right abdomen, fever, or yellowing of skin/eyes (possible gallbladder disease) Contact your doctor within 24-48 hours if you experience: Recurrent lightheadedness that occurs multiple times daily Dizziness that worsens over time rather than improving Lightheadedness accompanied by persistent nausea, vomiting, or diarrhea Symptoms that interfere with daily activities or quality of life New onset of dizziness after a dose increase Symptoms of hypoglycemia that do not improve with carbohydrate intake Before your appointment, document when the lightheadedness occurs (timing relative to medication administration, meals, or position changes), its severity and duration, and any accompanying symptoms

Kim S, Kang JY, Nguyen QA, Lee JS (2024) Effects of Prebiotic Dietary Fibers on the Stimulation of the Mucin Secretion in Host Cells by In Vitro Gut Microbiome Consortia
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