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While these studies provide insights into the peptides biological activity, further research continues to explore its mechanisms and interactions within complex cellular systems

In younger cells, FOXO4 appeared to be mostly in the cytoplasm, while in older cells it was more often in the nucleus, which may be considered its more active form

A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

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