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Vitamin B6 (pyridoxine) serves as a necessary cofactor in the folate cycle, playing a role in neurotransmitter synthesis, such as dopamine, serotonin, GABA, noradrenaline, and melatonin

Two animal studies, analysing the effect of TP508 loaded on PPF composite and microsphere scaffolds on segmental bone defects in rabbits, showed enhanced bone formation with a higher torsional stiffness of bone [99, 101]

In this review, we take a look beyond psychopharmacological interventions and discuss dietary and physical therapy approaches