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Nature 399 , 601605

A clinical study involving 50 human subjects using 4% Syn-AKE topically twice daily for 28 days demonstrated[5]: Wrinkle depth reduction of up to 52% on forehead expression lines Smoothing effect measurable in 80% of participants Wrinkle reduction evident in 73% of subjects Superior efficacy compared to acetyl hexapeptide-8 (Argireline) in head-to-head comparison Skin surface measurement studies using profilometry showed improvements in skin roughness parameters (Ra, Rz, and Rt measurements), with effects visible as early as 1-2 hours post-application continuing through 28 days of use[5]

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