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At week 72, the clinical data showed that 36.8% of patients receiving semaglutide achieved fibrosis improvement without worsening of NASH and 62.9% achieved NASH resolution without worsening of fibrosis, compared with 22.4% and 34.3%, respectively, in the placebo group (Sanyal et al., 2025)

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Similarly, individuals whose lesions show high expression of senescence markers like p16INK4a or SA--Gal activity might be prioritized for senolytic treatments, ensuring a more personalized and effective approach