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(17) Encourages a More Effective Breakdown of Alcohol In an experimental study on rats exposed to alcohol, administration of glutathione enhanced the activity of key alcoholmetabolizing enzymes, such as: Alcohol dehydrogenase (ADH) Aldehyde dehydrogenase (ALDH) As we know, these enzymes are central to converting ethanol to acetaldehyde and then to the less toxic acetate, via alcohol metabolism pathways in the liver