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The rigorous nature of this process is designed to safeguard public health and ensure that medications are both effective and safe for widespread use

Rare side effects include pancreatitis, acute kidney injury, worsening diabetes-related retinopathy and medullary thyroid cancer

NICE guidance provides clear recommendations for GLP-1 use, which focus exclusively on glycaemic control in type 2 diabetes (NG28) and weight management in obesity (TA875 for semaglutide, TA664 for liraglutide)

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