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Researchers at the University of Virginia, supported by National Institutes of Health funding, found that oral small-molecule GLP-1 receptor agonists, including orforglipron, penetrate deeper into the brain than previously understood

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While relationships were not as robust as for the matched-time analyses, fasting levels of 17 metabolites were positively correlated with glucose at 120 minutes, including lactate, AAs (Gln, Pro, Trp, Tyr, betaine), carnitine, and multiple lipids (lysophosphatidylcholine [LPC] 18:0, 18:2, 20:3, and 22:6

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