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The current standard of care for locally-advanced rectal cancer is neoadjuvant chemoradiation therapy (neoCRT), followed by surgical resection

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Members of the monomeric G-protein Rab family, specifically Rab8a, Rab13, and TBC1 domain family member 4 (encoded by the TBC1D4 gene) have been shown to be critical to the insulin-stimulated mobilization of GLUT4 to the plasma membrane in skeletal muscle while Rab10 is involved in the process in adipocytes