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Assessment of mixed infections by NGS NS5B amplicons, as well as 5NC-core ones if necessary (spanning the first 130 bp of the core region), were subjected to NGS and subtype calling using the methodology and primers previously described 30

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Its enzymatic function is based on two aspects: its catalytic activity and the auto- S -glutathionylation of GST by itself on Cys47 and Cys10, both of which disturb the subsequent interaction with c-Jun NH 2 -terminal kinase (JNK), resulting in the formation of a GST multimer 30 (Figure 3)

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