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Peroxidation cascade Once incorporated into the membrane, PL-PUFAs are oxidized to phospholipid hydroperoxides (PL-PUFA-OOH) through enzymatic or non-enzymatic pathways

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Payton JI, Abraham JT, Novak MD, Monsivais SE, Hammonds KP, Altman AM

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SLC7A11 is essential for cellular resistance to ferroptosis, and its inhibition represents a potential therapeutic target

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